[Jacob-list] GB item: G444R mutation (Tay-Sachs) in Jacob sheep

[Linda]

I am not alarmed, but wonder if you might share with us early signs of 
TSD in lambs as well as when we might expect to see signs. I believe a 
concerned breeder in CO had a lamb tested for TSD. The lamb was negative 
and the results showed a copper deficiency or some such, I think. J - 
jump in here, please. We do need to be aware of TSD, whether or not we 
tested, and we also have to be aware of other possibilities for the 
symptoms.

Turner 183K shows up in the background of every major flock in the 
country if you merge JSC and JSBA records.

Linda



Jacobflock at aol.com wrote:

> Great Britain Listers, Jean Blacknell and JSS members - The Jacob 

> (American) testing for the Tay-Sachs mutation has hit the 100 carrier 

> mark out of 561 tests; the common source continues to be Turner 183K; 

> son of imports Trevor UK 326 and Limper B97 GB2111.  The mutation in 

> North America has been reviewed by the JSBA and they have considered 

> this lethal congenital neurological problem to be 

> non-concerning.  Following JSBA counsel, Jacob breeders in North 

> America apparently need not be alarmed. 

>  

> Jacob breeders in GB might be interested in a developing study; Jean 

> Blacknell, Field Supervisor, has been aware of possible GM2 in Jacobs 

> for about two years.  For GB breeders .... I received the following 

> note from England today: .....  I was interested in the Vet Path paper 

> on the GM2 problem.  We identified an LSD Jacob sheep in the UK and in 

> cooperation with Guys Hospital ran plasma for HexA and Hex B and 

> discovered  the TSD variant in the Jacob.  The flock is quite small 

> (100 ewes, rams and lambs) but had two confirmed cases of LSD.  I note 

> the high carraige of the mutation in the US but no records of 

> importation from the US.  Coincidence? ......  Mark. 

>  

> I told Mark that we think the source is the UK and our US incidence is 

> through Turner 183K. 

>  

> Regards

> Fred Horak

> St. Jude's Farm

> 1165 E. Lucas Road

> Lucas, TX  75002

> Ph 972-727-0900

>  

>  

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-- 
Patchwork Farm Jacob Sheep <http://www.patchworkfibers.com>
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