[Jacob-list] GB item: G444R mutation (Tay-Sachs) in Jacob sheep

[Jacobflock at aol.com]

Great Britain Listers, Jean Blacknell and JSS members - The Jacob  
(American) testing for the Tay-Sachs mutation has hit the 100 carrier mark out  of 
561 tests; the common source continues to be Turner 183K; son of imports  
Trevor UK 326 and Limper B97 GB2111.  The mutation in North America has  been 
reviewed by the JSBA and they have considered this lethal congenital  
neurological problem to be non-concerning.  Following JSBA  counsel, Jacob breeders 
in North America apparently need not be  alarmed.  
 
Jacob breeders in GB might be interested in a developing study; Jean  
Blacknell, Field Supervisor, has been aware of possible GM2 in Jacobs for about  
two years.  For GB breeders .... I received the following note from England  
today: .....  I was interested in the Vet Path paper on the GM2  problem.  
We identified an LSD Jacob sheep in the UK and in cooperation  with Guys 
Hospital ran plasma for HexA and Hex B and discovered  the TSD  variant in the 
Jacob.  The flock is quite small (100 ewes, rams and lambs)  but had two 
confirmed cases of LSD.  I note the high carraige of the  mutation in the US 
but no records of importation from the US.  Coincidence?  ......  Mark.  
 
I told Mark that we think the source is the UK and our US  incidence is 
through Turner 183K.  
 
Regards
Fred Horak
St. Jude's Farm
1165 E. Lucas Road
Lucas, TX  75002
Ph 972-727-0900
 
 
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