[Jacob-list] G444R mutation (Tay-Sachs) in Jacob sheep

[Linda]

Will these 55 carriers be bred together to produce tay-sachs sheep for 
research?

Linda

Jacobflock at aol.com wrote:

> Dear Listers - The American Livestock Breeds Conservancy will be 

> carrying another short article on the Tay-Sachs / Jacob sheep in their 

> next issue of the NEWS.  The article will point out that about 500 DNA 

> tests were done, 90% of the flocks had at least one carrier; 11% of 

> those tested carried the mutation and, as I recall, carriers had 17 

> flock names.  Some Jacob breeders are concerned inasmuch as the 

> disease is in one of the four major Jacob lines and demonstrates a 

> founder effect.  Others are not concerned.  Members of the JSBA were 

> counseled to be aware of the problem but it is not something to be 

> concerned about since it is not a common problem.  Some of you got the 

> molecular genetics article about Tay-Sachs in Jacob Sheep on-line and 

> a few are now also aware that the clinical pathology paper on GM2 in 

> Jacobs is on-line through Veterinary Pathology.

>  

> The free DNA testing period which ran for 2009 and 2010 is being 

> curtailed since supplies sent out have not been sent back and there 

> have been no new requests.  Cryo preservation sites that previously 

> stored Jacob materials have been notified; mutatant Jacob semen and 

> embryos have been cryo preserved. 

>  

> This note is just a heads-up (because some people were upset when the 

> first report of TSD in Jacobs came out and they didn't know about it 

> beforehand) and probably the last that will appear for the next few 

> years.  Work and research on these neural diseases will continue but 

> interest and concern is limited.  If you wish to follow up on this or 

> other congenital problems in Jacobs, let me know.  Happy Holidays. 

>  Regards - Fred Horak

>  

>  

> In a message dated 9/10/2010 8:20:32 A.M. Central Standard Time, 

> Jacobflock at aol.com writes:

>

>     Dear listers - For those who may be interested, if you google

>     "Tay-Sachs + Jacob sheep" you will find a reference to the recent

>     article in Molecular Genetics and Metabolism which describes

>     identifying the problem, carrier testing, and its implications. 

>     You can get an abstract of the article for free but there is a

>     charge if you want the complete article from the on-line service. 

>     When the published article is available I will try to pass it on

>     ...  Regards, Fred Horak

>

> ------------------------------------------------------------------------

>

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Patchwork Farm Jacob Sheep <http://www.patchworkfibers.com>
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