[Jacob-list] Experiments to treat Tay-Sachs disease in Jacob sheep

[Gary Anderson]

Thanks, Fred, for the update on Tay-Sachs research in Jacob sheep.  I
surmise if a major news network were to pick up and report the results it
would have been done by now.  Nevertheless, the results reported in the
abstract are truly exciting.  Anyone who perused the list of abstract titles
to find the one of interest noticed that not many animal models for human
disease use sheep or other large animals.  As federal funds for research in
animal agriculture have stagnated or dwindled, many researchers have turned
to use of large animals as biomedical models for human disease.  Sometimes
applications are quite a stretch.  The Jacob model is unique in that it so
closely mimics and is the best model currently available for the human
disease.  You are owed a debt of gratitude for your persistence, sometimes
single-handed, in keeping this long-term project going.

-----Original Message-----
From: jacob-list-bounces at jacobsheep.com
[mailto:jacob-list-bounces at jacobsheep.com] On Behalf Of
jacob-list-request at jacobsheep.com
Sent: Friday, June 07, 2013 5:24 PM
To: jacob-list at jacobsheep.com
Subject: Jacob-list Digest, Vol 111, Issue 4

Send Jacob-list mailing list submissions to
	jacob-list at jacobsheep.com

To subscribe or unsubscribe via the World Wide Web, visit
	http://www.pairlist.net/mailman/listinfo/jacob-list
or, via email, send a message with subject or body 'help' to
	jacob-list-request at jacobsheep.com

You can reach the person managing the list at
	jacob-list-owner at jacobsheep.com

When replying, please edit your Subject line so it is more specific
than "Re: Contents of Jacob-list digest..."


Today's Topics:

   1. "Tay-Sachs" disease in Jacob Sheep successfully treated
      (Frederick Horak)
   2. Re: "Tay-Sachs" disease in Jacob Sheep successfully	treated
      (Zach Oaster)
   3. Re: "Tay-Sachs" disease in Jacob Sheep successfully	treated
      (Frederick Horak)
   4. Re: "Tay-Sachs" disease in Jacob Sheep successfully	treated
      (Frederick Horak)
   5. Re: "Tay-Sachs" disease in Jacob Sheep successfully	treated
      (Frederick Horak)


----------------------------------------------------------------------

Message: 1
Date: Fri, 7 Jun 2013 15:19:33 -0400 (EDT)
From: Frederick Horak <jacobflock at aol.com>
Subject: [Jacob-list] "Tay-Sachs" disease in Jacob Sheep successfully
	treated
To: jacob-list at jacobsheep.com, fhorak at aol.com
Message-ID: <8D031CB13A75585-848-1AA4C at webmailstg-m01.sysops.aol.com>
Content-Type: text/plain; charset="us-ascii"

TSD is a neurological disease and heretofore seemed insulated from treatment
because of the blood brain barrier.  At the 5/15/2013 meeting of the
American Society of Gene and Cell Therapy Dr. Douglas Martin (Auburn)
formally reported the successful treatment of Tay-Sachs affected Jacobs, the
first successful treatment of this disease and by gene therapy.   You can
find the complete report at the web site for the ASGCT meeting.  Regards -
Fred Horak
-------------- next part --------------
An HTML attachment was scrubbed...
URL:
<http://www.pairlist.net/pipermail/jacob-list/attachments/20130607/aa446c5c/
attachment-0001.htm>

------------------------------

Message: 2
Date: Fri, 7 Jun 2013 15:38:09 -0400
From: Zach Oaster <zach at fattoaster.com>
Subject: Re: [Jacob-list] "Tay-Sachs" disease in Jacob Sheep
	successfully	treated
To: Frederick Horak <jacobflock at aol.com>
Cc: jacob-list at jacobsheep.com, fhorak at aol.com
Message-ID:
	<CAKd_UXxhRS9RcY8OvSCSP-FjmgjAXMBgEAKOVbJW+YtvbQc10Q at mail.gmail.com>
Content-Type: text/plain; charset="iso-8859-1"

WOW, that is amazing news. Do they have a timeline in terms of how long it
might be before they can translate that into a human treatment?

^~^~^~^~^~^~^~^~^~^~^
Zach Oaster
zach at fattoaster.com
^~^~^~^~^~^~^~^~^~^~^
Visit Zach & Lindsay's farm blog: http://www.fattoasterfarm.com
^~^~^~^~^~^~^~^~^~^~^


On Fri, Jun 7, 2013 at 3:19 PM, Frederick Horak <jacobflock at aol.com> wrote:


> TSD is a neurological disease and heretofore seemed insulated from

> treatment because of the blood brain barrier.  At the 5/15/2013 meeting of

> the American Society of Gene and Cell Therapy Dr. Douglas Martin (Auburn)

> formally reported the successful treatment of Tay-Sachs affected Jacobs,

> the first successful treatment of this disease and by gene therapy.   You

> can find the complete report at the web site for the ASGCT

> meeting.  Regards - Fred Horak

> _______________________________________________

> Jacob-list mailing list, sponsored by Swallow Lane Farm & Fiberworks

> Jacob-list at jacobsheep.com

> http://www.pairlist.net/mailman/listinfo/jacob-list

>

>

-------------- next part --------------
An HTML attachment was scrubbed...
URL:
<http://www.pairlist.net/pipermail/jacob-list/attachments/20130607/b3bc1265/
attachment-0001.htm>

------------------------------

Message: 3
Date: Fri, 7 Jun 2013 16:22:35 -0400 (EDT)
From: Frederick Horak <jacobflock at aol.com>
Subject: Re: [Jacob-list] "Tay-Sachs" disease in Jacob Sheep
	successfully	treated
To: runzicker at verizon.net, jacob-list at jacobsheep.com
Message-ID: <8D031D3E1F4D1B9-1B0C-1B1D6 at webmailstg-d02.sysops.aol.com>
Content-Type: text/plain; charset="us-ascii"


Sorry Royal and Listers - the "thanks for the link" apparently said it all.
Try http://www.abstarcts2view.com/asgct/view.php?nu=ASGCT13L1_40


-----Original Message-----
From: Royal Unzicker <runzicker at verizon.net>
To: Frederick Horak <jacobflock at aol.com>
Sent: Fri, Jun 7, 2013 2:35 pm
Subject: Re: [Jacob-list] "Tay-Sachs" disease in Jacob Sheep successfully
treated



Thanks for the link, Fred.
 How are things in Texas?  Lots of nice lambs this year?
Royal
  
----- Original Message ----- 
  
From:   Frederick   Horak 
  
To: jacob-list at jacobsheep.com ; fhorak at aol.com 
  
Sent: Friday, June 07, 2013 3:19 PM
  
Subject: [Jacob-list] "Tay-Sachs" disease   in Jacob Sheep successfully
treated
  


TSD is a neurological disease and   heretofore seemed insulated from
treatment because of the blood brain   barrier.  At the 5/15/2013 meeting of
the American Society of Gene and   Cell Therapy Dr. Douglas Martin (Auburn)
formally reported the   successful treatment of Tay-Sachs affected Jacobs,
the first successful   treatment of this disease and by gene therapy.   You
can find   the complete report at the web site for the ASGCT   meeting.
Regards - Fred Horak   
  

  
_______________________________________________
Jacob-list mailing   list, sponsored by Swallow Lane Farm &   Fiberworks
Jacob-list at jacobsheep.com
http://www.pairlist.net/mailman/listinfo/jacob-list


-------------- next part --------------
An HTML attachment was scrubbed...
URL:
<http://www.pairlist.net/pipermail/jacob-list/attachments/20130607/4fb9be43/
attachment-0001.htm>

------------------------------

Message: 4
Date: Fri, 7 Jun 2013 16:41:14 -0400 (EDT)
From: Frederick Horak <jacobflock at aol.com>
Subject: Re: [Jacob-list] "Tay-Sachs" disease in Jacob Sheep
	successfully	treated
To: zach at fattoaster.com
Cc: jacob-list at jacobsheep.com, fhorak at aol.com
Message-ID: <8D031D67CFE9852-1B0C-1B344 at webmailstg-d02.sysops.aol.com>
Content-Type: text/plain; charset="us-ascii"


Dear Zach Oaster - The work on the sheep model has been successful for two
years and they began primate studies six or eight months ago.  One of the
monkeys died.  The phase one human trial which was targeted for this Fall
depended on the successful primate tests.   The collaborators think they
know why the monkey died and tests on primates are being rescheduled for
this Fall.  In the meantiome, they are continuing work on the sheep model;
therapies for delivery of the vectore are being refined to avoid surgical
intrusion and test an injection method.  

The research on this model is going in several different directions from
vector to delivery and delivery of therapies for the more than forty related
neural diseases.  The monogenic types, like the Jacob model, are easiest to
solve but explosions in the human genome and role of genes unknown just
years ago is enabling many breakthroughs.
Regards - Fred Horak

-----Original Message-----
From: Zach Oaster <zach at fattoaster.com>
To: Frederick Horak <jacobflock at aol.com>
Cc: jacob-list <jacob-list at jacobsheep.com>; fhorak <fhorak at aol.com>
Sent: Fri, Jun 7, 2013 2:38 pm
Subject: Re: [Jacob-list] "Tay-Sachs" disease in Jacob Sheep successfully
treated


WOW, that is amazing news. Do they have a timeline in terms of how long it
might be before they can translate that into a human treatment?



^~^~^~^~^~^~^~^~^~^~^
Zach Oaster
zach at fattoaster.com
^~^~^~^~^~^~^~^~^~^~^
Visit Zach & Lindsay's farm blog: http://www.fattoasterfarm.com
^~^~^~^~^~^~^~^~^~^~^




On Fri, Jun 7, 2013 at 3:19 PM, Frederick Horak <jacobflock at aol.com> wrote:

TSD is a neurological disease and heretofore seemed insulated from treatment
because of the blood brain barrier.  At the 5/15/2013 meeting of the
American Society of Gene and Cell Therapy Dr. Douglas Martin (Auburn)
formally reported the successful treatment of Tay-Sachs affected Jacobs, the
first successful treatment of this disease and by gene therapy.   You can
find the complete report at the web site for the ASGCT meeting.  Regards -
Fred Horak
_______________________________________________
Jacob-list mailing list, sponsored by Swallow Lane Farm & Fiberworks
Jacob-list at jacobsheep.com
http://www.pairlist.net/mailman/listinfo/jacob-list




-------------- next part --------------
An HTML attachment was scrubbed...
URL:
<http://www.pairlist.net/pipermail/jacob-list/attachments/20130607/d2d93e46/
attachment-0001.htm>

------------------------------

Message: 5
Date: Fri, 7 Jun 2013 17:23:55 -0400 (EDT)
From: Frederick Horak <jacobflock at aol.com>
Subject: Re: [Jacob-list] "Tay-Sachs" disease in Jacob Sheep
	successfully	treated
To: jacob-list at jacobsheep.com
Message-ID: <8D031DC7335DF67-DAC-1A829 at webmailstg-d05.sysops.aol.com>
Content-Type: text/plain; charset="us-ascii"


Old timers case number 3,475: I corrected the link site below. I misspelled
'abstracts'.  





  
----- Original Message ----- 
  
From:   Frederick   Horak 
  
To: runzicker at verizon.net ; jacob-list at jacobsheep.com 
  
Sent: Friday, June 07, 2013 4:22 PM
  
Subject: Re: [Jacob-list] "Tay-Sachs"   disease in Jacob Sheep successfully
treated
  


  
Sorry Royal and Listers - the "thanks for the link" apparently said   it
all.  Try http://www.abstracts2view.com/asgct/view.php?nu=ASGCT13L1_40
  
  
  
-----Original   Message-----
From: Royal Unzicker <runzicker at verizon.net>
To:   Frederick Horak <jacobflock at aol.com>
Sent: Fri, Jun   7, 2013 2:35 pm
Subject: Re: [Jacob-list] "Tay-Sachs" disease in Jacob   Sheep successfully
treated

  
  
  
Thanks for the link,   Fred.
  
 How are things in   Texas?  Lots of nice lambs this year?
  
Royal
  
    
-----     Original Message ----- 
    
From:     Frederick     Horak 
    
To:     jacob-list at jacobsheep.com ; fhorak at aol.com 
    
Sent:     Friday, June 07, 2013 3:19 PM
    
Subject:     [Jacob-list] "Tay-Sachs" disease in Jacob Sheep successfully
treated
    


TSD is a neurological disease and     heretofore seemed insulated from
treatment because of the blood brain     barrier.  At the 5/15/2013 meeting
of the American Society of Gene and     Cell Therapy Dr. Douglas Martin
(Auburn)     formally reported the successful treatment of Tay-Sachs
affected Jacobs, the first successful treatment of this disease and     by
gene therapy.   You can find the complete report at the     web site for the
ASGCT meeting.  Regards - Fred     Horak     
    
    
_______________________________________________
Jacob-list     mailing list, sponsored by Swallow Lane Farm & Fiberworks
Jacob-list at jacobsheep.com
http://www.pairlist.net/mailman/listinfo/jacob-list






-------------- next part --------------
An HTML attachment was scrubbed...
URL:
<http://www.pairlist.net/pipermail/jacob-list/attachments/20130607/4d0ee8c9/
attachment.htm>

------------------------------

_______________________________________________
Jacob-list mailing list
Jacob-list at jacobsheep.com
http://www.pairlist.net/mailman/listinfo/jacob-list


End of Jacob-list Digest, Vol 111, Issue 4
******************************************