[Jacob-list] Last piece of the GM2 ganglipsidosis puzzle

[Jacobflock at aol.com]

Dear Jacob-listers = Several listers are acutely aware of the fatal  
congenital problem in Jacobs in North America; the G444R commonly referred to as  
the Tay-Sachs mutation.  The source of the problem here in America can be  
traced to the ram Turner 183K; the problem had spread to 15 of 16 flocks 
tested,  over 150 carriers in about 600 tests, and has spread from East to West  
coast.
 
Two veterinarians in England, Drs. Wessells and Holmes are presenting their 
 findings at a meeting in London:  "GM2 gangliosidosis (Tay-Sachs disease)  
in European Jacob sheep"  They describe finding TSD in Jacobs  using human 
blood and brain tissue analysis.  They brought Jacob  material to Guys 
Hospital (a human hospital) and ran human analytical tests  which the sheep blood 
and tissue "flunked",  At first, they thought the TSD  on England came from 
North America where it was first reported but now accept  that it came from 
Great Britain to North America.  They too will be looking  for a source and 
founder which may be years in finding.
 
The ALBC will be covering the final chapter of the mutation findings,  
future testing, the results of the gene therapy protocol and Mark Wessells  and 
Paul Holmes' findings in an upcoming NEWS letter.  
Regards = Fred Horak
 
 
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://www.pairlist.net/pipermail/jacob-list/attachments/20110909/8ff96ebb/attachment.htm>